Categorical data were expressed as numbers. Continuous data were expressed as medians and ranges. Cox proportional hazards regression analyses were used to identify factors associated with the development of HCC within 5 years of achieving SVR. Cumulative HCC incidence rates were generated using the Kaplan–Meier method and compared using the log-rank test. A receiver operating characteristic (ROC) curve was used to determine the optimal cutoff value of the new formula score for predicting HCC. Statistical significance was set at p < 0.05.>
Patient properties
The participants incorporated 172 men and you may 127 women. The new average patient ages are 68 years (range: 27–ninety many years). The fresh new median observation several months was 29 months (range: step 1.0–72.0 days) following end out-of SVR. The fresh DAA therapy routines was daclatasvir/asunaprevir for the 41 people, elbasvir/grazoprevir for the thirty six, glecaprevir/pibrentasvir into the 63, sofosbuvir/ledipasvir inside the 47, ombitasvir/paritaprevir/ritonavir ± ribavirin for the 65, and you may sofosbuvir/ribavirin during the 47 clients. The newest average platelet number before beginning of the DAA cures is 154?10 step 3 /?L (47–496?10 3 /?L), FIB-cuatro Directory PowerPoint slide larger photo original photo Table step one. Baseline attributes of the clients.
Cumulative HCC occurrence are 4.3% at 1 year, nine.7% on 36 months, and you will 12.5% within 5 years following completion out-of SVR (Fig 1). The cumulative incidence off HCC is notably higher regarding the clients which have a history of HCC (thirty five.9%, 72.2%, and 72.2% at the one to, about three, and you may five years) compared with step 1.6%, 4.8%, and seven.8% for the, clients untreated history of HCC. The new ratio try rather highest inside clients with a history of HCC medication (P = dos.52?ten ?26 , Fig dos).
Issues with the HCC adopting the conclusion off SVR
On the univariate study of your own factors with the HCC immediately after SVR, years, past therapy reputation of HCC, ? GTP, the liver cirrhosis, the fresh new formula get, APRI, ALBI rating, and you will FIB-cuatro list was in fact defined as extreme issues in most 299 customers. Multivariate data indicated that previous therapy reputation of HCC (threat ratio [HR] = , 95% confidence interval [CI] = 5.560–, P = cuatro.72?ten ?8 ), ? GTP (Time = step 1.005, 95% CI = step one.00step one–step 1.008, P = 0.010), this new formula rating (Hours = 1.389, 95% CI = step 1.00step 1–step 1.925, P = 0.049), and you will ALBI score (Time = step three.102, 95% CI = step 1.055–9.125, P = 0.040) was basically defined as separate affairs regarding the growth of HCC immediately following DAA procedures (Dining table 2).
Dining table 2. Univariate and you can multivariate analyses using Cox proportional hazards regression away from standard products on the development of hepatocellular carcinoma among the 299 people.
2nd, we analyzed affairs associated with development of HCC within the 274 customers in place of a history of HCC treatment. About univariate study, decades, male gender, the liver cirrhosis, the new algorithm score, APRI, and ALBI get was basically identified as significant activities. Multivariate study revealed that men (Hour = 6.584, 95% CI = 1.291–, P = 0.023) and you may the brand new algorithm score (Hour = 1.741, 95% CI = 1.041–2.911, P = 0.035) had been recognized as separate issues of the growth of HCC (Table step three). Evaluate the newest overall performance ones factors for example FIB-cuatro list, brand new formula get and liver cirrhosis towards the predicting HCC advancement and you will prevent collinearity we oriented about three models of uni-multivariate analyses (design 1 boasts FIB-4, model dos comes with the latest formula, and design step 3 is sold with presence regarding the liver cirrhosis) (S1 Table). To possess univariate data, age, sex, diabetic issues condition, ?GTP, and AFP was indeed inserted, and you can FIB-cuatro index, new algorithm get, and you may liver cirrhosis was indeed added to each one of the about three habits. As a result, brand new algorithm rating met with the reasonable p value (p = 9.40?10 ?4 ), indicating which have greatest symptomatic performance versus FIB-4 directory (p = step one.99?10 ?step 3 ) or the exposure regarding cirrhosis (p = 0.015).